prefrontal cortex

noun

: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning

Examples of prefrontal cortex in a Sentence

Recent Examples on the Web
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Short-term working memories primarily involve the prefrontal cortex. Laura Baisas, Popular Science, 24 Sep. 2025 In the present trial, the researchers delivered mild electrical currents to a specific brain area, the left dorsolateral prefrontal cortex (DLPFC), a region often linked to mood regulation. New Atlas, 16 Sep. 2025 The Brain Science Behind Performance From a neuroscience perspective, engagement depends on consistent access to the prefrontal cortex, where problem-solving and decision-making happen. Heather Yerrid, Forbes.com, 8 Sep. 2025 The process involves two key parts of the brain — the auditory cortex, which processes sounds, and the prefrontal cortex, which controls attention and decision-making. Angelica Stabile, FOXNews.com, 31 Aug. 2025 See All Example Sentences for prefrontal cortex

Word History

First Known Use

1892, in the meaning defined above

Time Traveler
The first known use of prefrontal cortex was in 1892

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Cite this Entry

“Prefrontal cortex.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prefrontal%20cortex. Accessed 4 Oct. 2025.

Medical Definition

prefrontal cortex

noun
: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning
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